Intracytoplasmic Sperm Injection (ICSI) An advanced form of IVF, ICSI often offers hope where other assisted reproductive techniques have not been successful.

What is ICSI?

Intracytoplasmic sperm injection is an advanced fertility intervention similar to IVF. Where conventional IVF mixes the sperm with the egg in a specialised medium which still requires the sperm to swim to and penetrate the egg’s outer layers, ICSI enables us to carry fertilisation all the way by injecting a single sperm directly into the egg.

Though ICSI does not guarantee a pregnancy, it can significantly improve your chances compared to other forms of assisted reproduction, particularly if you are experiencing those situations listed to the right.

Dr Sacks may recommend ICSI if you:

  • Are affected by severe male fertility problems such as low sperm quality or quantity
  • Have not been successful with conventional IVF
  • Are using surgically retrieved sperm
  • Are using donor eggs that have been frozen and thawed

How does the ICSI process work?

1

Your initial consultation with Dr Sacks

Ask your GP or attending doctor to write you a referral to Dr Gavin Sacks, accompanied by a copy of your medical history and results of any previous fertility tests or treatments. This gives Dr Sacks a more complete picture of your current situation and helps to guide his investigations and recommendations without wasting precious time. 

Your first appointment is all about getting to know you and your partner (if applicable), your fertility journey so far, and how you would like to reach your goal of building your family. After confirming whether IVF is a suitable option for you, depending on the results of your fertility tests and your personal preferences, we can move forward with the first step of the IVF procedure.

2

Ovarian stimulation for the female partner

To retrieve multiple eggs for IVF, we need to encourage your body to produce more than the typical one egg per month. This is done through carefully timed injections of certain hormone medications self-administered at home. Some women feel anxious about using a needle but your dedicated IVF nurse will show you how to do your own injections with minimal discomfort. Throughout this step of your treatment, Dr Sacks will monitor the development of your ovarian follicles with ultrasound imaging and blood tests, and may fine-tune your medication dosages.

3

Egg collection

Once your ovarian follicles have reached the right size, you’ll be given an injection of human chorionic gonadotropin (hCG) hormone medication, commonly termed a ‘trigger injection’. This hormone matures and releases the available eggs to be collected during a minor surgical procedure in the hospital. The collection involves using a thin needle guided by a trans-vaginal ultrasound to retrieve the eggs directly from your ovaries.

4

Fertilisation

Your eggs are mixed with sperm – whether that produced by your partner or provided by a sperm donor – in a laboratory environment under the expert supervision of our embryologists. This gives the sperm the opportunity to fertilise the egg on its own. Each fertilised egg is then transferred to a Geri time-lapse incubator, an advanced piece of IVF technology exclusively used by the Genea Fertility network.

5

Embryo transfer

At day 5 of embryo development (the blastocyst stage), the healthiest embryo is selected by our embryologists for implantation. Dr Sacks uses a long, thin catheter gently passed through your cervix to place the embryo directly into your uterus. Most women feel little to no discomfort during the procedure and you are free to return to your day immediately after. Around two weeks later we will organise a pregnancy blood test for you.

Frequently Asked Questions

For couples facing severe male infertility, ICSI offers a better chance of pregnancy compared to IUI or IVF. Around 50-80% of eggs will fertilise normally with the ICSI procedure. From here, pregnancy rates are similar to that seen in women undergoing conventional IVF when not affected by male factor infertility. 

The ICSI procedure carries a small risk that your egg may be damaged from the needle insertion. There is a very slightly increased chance of a chromosomal abnormality in the sex chromosomes (X and Y chromosome), which may heighten the risk of a miscarriage or health conditions in the child.

The ovarian stimulation step carries a low potential for ovarian hyperstimulation syndrome, a reaction to the hormone medication that requires urgent medical attention. All of these risks will be discussed in depth with you before proceeding with ICSI.

Speak with Dr Gavin Sacks

Consultations are available at Bondi Junction and Sydney CBD.

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